2024 Sunitinib malate solubility in water

Sunitinib malate solubility in water

Author: ucri

August undefined, 2024

WebSunitinib (malate) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, sunitinib (malate) should first be dissolved in DMSO and then diluted … WebSUTENT (sunitinib 12.5 mg capsules) SUTENT (sunitinib 25 mg capsules) SUTENT (sunitinib 37.5 mg capsules) SUTENT (sunitinib 50 mg capsules) 2. QUALITATIVE AND …

Sunitinib Malate (SU 11248 Malate) PDGFR Inhibitor

Web1 Jun 2024 · Solubility of sunitininb malate (SM) in various cosolvents/mixtures was determined. • The mole fraction solubilities of SM were found highest in neat Transcutol … Web11 Nov 2024 · Sunb-malate, the water-soluble form of sunitinib, was shown to have higher intraocular penetration through transscleral diffusion following subconjunctival (SCT) … armani jogging suits

Sunitinib: Uses, Interactions, Mechanism of Action - DrugBank

WebSunitinib is a yellow to orange powder soluble in acidic aqueous solutions (pH 1.2 – 6.8) at 25mg/ml. The solubility of sunitinib rapidly decreases at pH greater than 6.8. For this … WebProduct information "Sunitinib, Malate Salt (Sunitinib Maleate, Sutent, SU-11248, PHA-290940AD, PNU-290940AD, CAS 341031-" Soluble in DMSO at 40 mg/mL, very poorly … Web1 Mar 2024 · The mole fraction solubilities of SM were obtained maximum in pure THP (1.87 × 10⁻²) followed by PEG-400, IPA, ethanol, PG, EG and water (1.05 × 10⁻⁵) at “T = 318.2 K”. … armani jp

Z 3H 1H H FN O C H O - Food and Drug Administration

Solubility determination, various solubility parameters and solution …

WebSunitinib malate is a hydrophobic drug with very poorly water-soluble properties. I'm going to incorporate sunitinib into beta-cyclodextrin (inclusion complex CD/Drug) then, loaded this... Web21 Sunitinib is a versatile tyrosine kinase inhibitor, sold under the brand name Sutent® by Pfizer as 22 its malate salt form.1 It is currently used to treat renal cell carcinoma and … balu 14WebSunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of … baltz rebekah g

"WebThe solubility of sunitinib malate in aqueous media over the range pH 1.2 to pH 6.8 is in excess of 25 mg/mL. The log of the distribution coefficient (octanol/water) at pH 7 is 5.2. … " - Sunitinib malate solubility in water

Sunitinib malate solubility in water

Web9 Sep 2024 · The chemical structure of sunitinib malate is: Sunitinib malate is a yellow to orange powder with a pKa of 8.95. The solubility of sunitinib malate in aqueous media … WebSunitinib malate is a yellow to orange powder with a pKa of 8.95. The solubility of sunitinib malate in aqueous media over the range pH 1.2 to pH 6.8 is in excess of 25 mg/mL. The …

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WebSolubility (25°C) DMSO 15 mg/mL Water <1 mg/mL Ethanol <1 mg/mL Storage Description Sunitinib Malate (Sutent, SU11248) is a potent RTK inhibitor targeting VEGFR2 (Flk-1) and … Web10 Nov 2024 · Sunitinib malate 341031-54-7 Not Listed STOT RE. 1 (H372) Repr 1B (H360D) Aquatic Acute 1 (H400) Acute Chronic 1 (H410) 15-40 Magnesium stearate 557-04-0 209 …

WebSunitinib malate: Capsule: 12.5 mg/1: Oral: Northstar RxLLC: 2024-02-18: Not applicable: US: Sunitinib Malate: Capsule: 37.5 mg/1: Oral: Mylan Pharmaceuticals Inc. 2024-01-04: Not … Web13 Mar 2015 · It also is a potent, ATP-competitive inhibitor of VEGFR, PDGFR-β and c-Kit (KIT). Sunitiba Malate inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. …

WebSunitinib malate has been used: to study its mechanism in the inhibition of MCF-7 cell migration and angiogenesis; as a reference molecule to compare its docking energies … WebFDA Approved Yes FDA label information for this drug is available at DailyMed. Use in Cancer Sunitinib malate is approved to treat adults with: Gastrointestinal stromal tumor …

WebThe solubility of sunitinib malate in aqueous media over the range pH 1.2 to pH 6.8 is in excess of 25 mg/mL. The log of the distribution coefficient (octanol/water) at pH 7 is 5.2. …

WebSunitinib malate (SM) is reported as a weakly soluble drug in water due to its poor dissolution rate and oral bioavailability. Hence, in the current study, various "self … armani jordanWebSunitinib Malate 100 mM solution in DMSO (25 mg in 469.4 µl) 25 mg See below SECTION 3: HAZARDS IDENTIFICATION Product Name/Chemical Name CAS Number EC-No. MW … balu 16WebIn this article, details of crystal and molecular structures of sunitinib malate (SUM), an anticancer therapeutic, and its key synthetic intermediate are presented. Both these … balu 13WebFor research use only. Sunitinib (SU11248) malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 … balu 19WebDescription. Sunitinib Malate (SU 11248 Malate) is a multi-targeted receptor tyrosine kinase inhibitor with IC50 s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively [1]. … balu 15WebSunitinib Accord 25 mg hard capsules . Capsule content: cellulose microcrystalline, mannitol (E421), croscarmellose sodium, povidone (E1201) and magnesium stearate. Capsule … balu 2001 kftWebSunitinib, sold under the brand name Sutent, is a medication used to treat cancer. It is a small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved … balu 17