WebMay 1, 2024 · Methods Relaxin-2 serum levels were measured in 85 chronic HFpEF patients from a prospective cohort study (NETDiamond). Clinical, imaging, and analytical data … WebMay 1, 2024 · Relaxin-2 serum levels were measured in 85 chronic HFpEF patients from a prospective cohort study (NETDiamond). Clinical, imaging, and analytical data were compared across relaxin-2 tertiles. The primary outcome was a composite of cardiovascular death, HF hospitalisation, acute HF episode or diuretic intensification and the secondary …
Relaxin/serelaxin for cardiac dysfunction and heart failure in ...
WebFeb 2, 2024 · A randomized, international, blinded, sham-controlled trial conducted in 89 medical centers across 4 continents, REDUCE LAP-HF II was designed to assess the effects of shunt device placement on outcomes among patients with symptomatic HFpEF. For inclusion in the trial, patients needed to be at least 40 years of age or older, have an … WebMay 1, 2024 · This review focuses on basic research, pre-clinical and clinical findings that may account for the potential benefit of relaxin-2 in HFpEF. The peptide combines short … hospices northwest
Relaxin-2 for heart failure with preserved ejection fraction (HFpEF ...
WebJan 1, 2024 · However, relaxin also has important cardiovascular effects as part of the adaptation that the cardiovascular system undergoes in response to the extra demands of pregnancy. These effects are primarily mediated by the relaxin family peptide receptor 1, which is one of four known relaxin receptors. The effects of relaxin on the cardiovascular ... WebMar 22, 2024 · Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome in which patients have symptoms and signs of heart failure, with left ventricular ejection fraction ≥50%. The most common risk factors are advanced age, female sex, hypertension, obesity, chronic kidney disease, diabetes mellitus, and coronary artery … WebSerelaxin induced a similar dyspnoea relief in HFpEF vs. HFrEF patients by visual analogue scale-area under the curve (VAS-AUC) through Day 5 [mean change, 461 (-195, 1117) vs. … psychiatry drug classes