Hipk2 relocalization
Webb1 mars 2007 · HIPK2 nuclear localization strongly increases HIPK2-induced apoptosis. ( A) Western blot analyses of endogenous HMGA1, HIPK2, and p53 in WT p53–carrying RKO cells transduced with HMGA1-specific sense or antisense oligonucleotides. γ-Tubulin was used as loading control. WebbHIPK2 binds and phosphorylates histone H2B at S14 (H2B-S14P), and the two proteins colocalize at the midbody. ... High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2. J. Clin. Invest. 2007; 117: 693-702. …
Hipk2 relocalization
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Webb15 mars 2024 · There were three expression patterns of HIPK2 including positive nucleus, positive both nucleus and cytoplasm, and only positive cytoplasm. The main positive location of normal epithelium cells... Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene. HIPK2 can be categorized as a Serine/Threonine Protein kinase, specifically one that interacts with homeodomain transcription factors. It belongs to a family of protein kinases known as the DYRK kinases. Within this family HIPK2 belongs to a group of homeodomain-interacting prote…
WebbInterestingly, at variance from DYRKs, inhibition of HIPK2-Y354 phosphorylation induces a strong out-of-target Y-kinase activity in cis and a strong cytoplasmic relocalization of the kinase. Together, these results demonstrate that the catalytic activity, substrate … Webb16 apr. 2010 · HIPK2 is considered a nuclear S/T kinase that binds and phosphorylates a still enlarging body of targets involved in the regulation of cell survival and proliferation during development and in response to genotoxic damage or hypoxia [1–4].
WebbWhen the cell is treated with TGF-β, HIPK2, a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). Miscellaneous mechanisms. Glucose breakdown produces ROS, which leads to Daxx … Webbeffects of HIPK2 on p53-dependent gene expression, suggesting that Axin stimulates HIPK2 by physically occupying an autoinhibitory domain of HIPK2.26 HIPK2 antagonizes Mdm2-mediated nuclearHIPK2 antagonizes Mdm2-mediated nuclear export and …
Webb1 sep. 2024 · The protein kinase homeodomain-interacting protein kinase 2 (HIPK2) plays an important role in development and in the response to external cues. The kinase associates with an exceptionally large number of different transcription factors and …
WebbCytoplasmic relocalization of HIPK2 induced by HMGA1 overexpression is a mechanism of inactivation of p53 apoptotic function that the authors believe to be novel. High-mobility group A1 (HMGA1) overexpression and gene rearrangement are frequent events in … jeanine skorinko wpiWebb31 okt. 2008 · HIPK2 activity is restrained in cancer cells through mutations, downregulation of its mRNA or overexpression of HMGA1, which relocalizes HIPK2 into the cytoplasm. The E3 ubiquitin ligases... jeanine smithWebbalytic activity of HIPK2, and the consequent determination of cell fates (Fig. 1). In this review we will focus on the determina-tion of cell fate—cell death or survival—by differential states of diverse HIPK2 post-translational modifications (termed the “HIPK2 … jeanine slikWebb1 feb. 2011 · HIPK2 functions as a general regulator of gene expression but also as a kinase that phosphorylates and regulates transcription factors such as p53 and IPF1/PDX (insulin promoter factor-1/pancreatic duodenal homeobox-1) [12], [13], [14]. jeanine smirlWebb4 apr. 2024 · HIPK2 is a serine/threonine kinase, located in the nucleus, that was initially found to be able to phosphorylate p53 at Ser46 to promote apoptosis; it has been widely studied. It has been reported that HIPK2 can simultaneously regulate TGF-β/Smad3, Wnt/β-catenin, Notch and NF-κB pathways in the kidney to initiate inflammation and … laboratorium bahasa inggrisnya adalahWebb13 aug. 2012 · Similar HIPK2 cytoplasmic localization was found in breast cancer tissues with overexpression of integrin alpha(6)beta(4), which is also involved in impairment of p53 apoptotic activity , indicating that HIPK2 cytoplasmic relocalization may be a negative … jeanine sneyd obituaryWebbHere we describe a mechanism through which HMGA1 inhibits p53-mediated apoptosis by counteracting the p53 proapoptotic activator homeodomain-interacting protein kinase 2 (HIPK2). We found that HMGA1 overexpression promoted HIPK2 relocalization in the cytoplasm and inhibition of p53 apoptotic function, while HIPK2… Expand jeanine smith md