WebGLYT2 is specifically expressed in glycinergic neurons and thus has been used as a marker of glycinergic neurons.... Gene Knock-in, Cre Recombinase and Transgenic … WebMar 13, 2013 · Optogenetic experiments were performed on GlyT2-cre transgenic mice (MMRRC Tg(Slc6a5-cre)KF109Gsat/Mmucd) containing a single copy of the cre transgene. ... (2003) Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality.
A glycine transporter 2-Cre knock-in mouse line for ... - PubMed
WebGlycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft … WebJul 16, 2014 · Both glycinergic and GABAergic neurons require the vesicular inhibitory amino acid transporter (VIAAT) for synaptic vesicle filling. Presynaptic GABA concentrations are determined by the GABA-synthesizing enzymes glutamate decarboxylase (GAD)65 and GAD67, whereas the presynaptic glycine content depends … service perishability examples
A glycine transporter 2-Cre knock-in mouse line for …
WebGlycine transporter 2 (GlyT2) mRNA is exclusively expressed in glycinergic neurons, and is presently considered a reliable marker for glycinergic neuronal somata. In this study, we have performed non-radioactive in situ hybridization to localize GlyT2 mRNA in fixed free-floating sections of cervical (C2 and C6), thoracic (T5), lumbar (L2 and L5) and sacral … WebThe glycine transporter 1 (GlyT1) is expressed in astrocytes and selected neurons of the mammalian CNS. In newborn mice, GlyT1 is crucial for efficient termination of glycine-mediated inhibitory neurotransmission. ... GlyT1((+)/(+)) mice expressing Cre recombinase in glial cells developed severe neuromotor deficits during the first postnatal ... WebThe Second Intracellular Loop of the Glycine Transporter 2 Contains Crucial Residues for Glycine Transport and Phorbol Ester-induced Regulation* Received for publication, … service performance review phrases