Egr2 macrophage
WebFeb 17, 2024 · The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization. … WebHere, we identify that the transcriptional factor EGR2 is an evolutionarily conserved feature of lung alveolar macrophages and show that cell-intrinsic EGR2 is indispensable for the tissue-specific identity of alveolar macrophages. Mechanistically, we show that EGR2 is driven by TGF- and GM-CSF in a PPAR- -dependent manner to control alveolar ...
Egr2 macrophage
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WebEGR2 (also termed Krox20) is a transcription regulatory factor, containing three zinc finger DNA-binding sites, and is highly expressed in a population of migrating neural crest cells. … WebEGR2; IL-4; macrophage polarization; epigenomic regulation; transcription factor network; Macrophages are innate immune cells that are highly heterogenous and plastic, able to …
WebMar 30, 2024 · Tan AHY, Tu W, McCuaig R, Hardy K, Donovan T, Tsimbalyuk S, Forwood JK, Rao S. Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer. Front Immunol. 2024 Jun 12;10:1351. doi: 10.3389/fimmu.2024.01351. eCollection 2024. WebNov 19, 2024 · EGR2 fulfills lung macrophage potential. Alveolar macrophages are important for maintaining lung homeostasis and protecting the lungs against injury and …
WebMar 21, 2024 · EGR2 (Early Growth Response 2) is a Protein Coding gene. Diseases associated with EGR2 include Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive and Charcot-Marie-Tooth … WebMeasurement of the dynamic expression levels of M1 macrophage specific marker genes CD38 and Gpr18 as well as M2 macrophage specific marker genes Egr2 and Myc suggested that M1 macrophages were highly involved at all tested time points after peripheral nerve injury while M2 macrophage might be more involved in the later phase …
WebJan 13, 2024 · A recent study ( 16) suggested that EGR proteins (specifically EGR2) may also function in human monocyte-to-macrophage differentiation based on the evidence that this …
WebMacrophage polarization to the M1-like phenotype after infection with E. faecalis was evident by the lower expression of EGR2; marker for M2 macrophages. A. Flow cytometry scattergrams showing the percentage % expressions of EGR2. B. Bar chart showing the mean percentage of F4/80-positive cell populations in the control and experimental … going deeper with convolutions citationWebATF3 and EGR2 gene expression levels in sdLDL-treated macrophages of patients with coronary artery stenosis Background: The metabolism of cholesteryl esters (CEs) is under the control of a gene network in macrophages. Several genes such as ATF3 and EGR2 are related to cholesterol metabolism. going deeper with convolutions原文WebLooking for online definition of EGR2 in the Medical Dictionary? EGR2 explanation free. What is EGR2? Meaning of EGR2 medical term. What does EGR2 mean? ... -17, -18a, … going deeper with convolutions cvprWebOct 14, 2024 · EGR2 is a direct target of IL-4-activated STAT6, having broad action indispensable for 77% of the induced gene signature of alternative polarization, including … going deeper with convolutions引用going deeper with image transformers githubhttp://genesdev.cshlp.org/content/early/2024/10/14/gad.343038.120 going deeper with convolutions 精读WebThe impact of IRF5 knockdown was most pronounced, curtailing the expression of other inflammatory mediators such as IL-6 and NOS2, especially in M1-polarized macrophages. Contrary to IRF5, EGR2 knockdown potentiated M1-associated markers while altogether abolishing M2 marker expression, which is indicative of the principal role of EGR2 in the ... going deeper with image transformers