WebThe C-terminus of Hsp70 Interacting Protein (CHIP) E3 ligase functions as a key regulator of protein quality control by binding the C-terminal M/IEEVD peptide motif of Hsp/c70(90) with its N-terminal tetratricopeptide repeat (TPR) domain and facilitating poly ubiquitination of misfolded client proteins via its C-terminal catalytic U-box. WebJan 25, 2024 · CHIP binding to tau D421 , but not tau FL , promoted its ubiquitination, while binding to caspase-6 D179 mediated ubiquitin-independent inhibition. Given that caspase activity generates tau D421 …
The E3 ligase CHIP: insights into its structure and regulation
WebMar 3, 2015 · CHIP ubiquitinates not just clients bound to Hsp70/Hsc70 but also Hsp70/Hsc70 themselves, targeting lysines in the SBDβ or lid subdomains (Kundrat and Regan, 2010a).Mutations of CHIP-TPR residues that interact with the GPTIEEVD motif are known to abolish the ubiquitination activity of CHIP towards chaperones or chaperone … WebThe City of Fawn Creek is located in the State of Kansas. Find directions to Fawn Creek, browse local businesses, landmarks, get current traffic estimates, road conditions, and … purdin poultry processing
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